240 Absence of human polyomaviruses in angiolymphoid hyperplasia with eosinophilia (ALHE)

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon skin disease that presents as papules or nodules in the head and neck region. The pathogenesis of vascular proliferation characterizes ALHE unclear, neoplastic reactive etiologies have both been proposed. Several human polymaviruses (HPyV), including HPyV6, HPyV7, trichodysplasia spinulosa polyomavirus (TSPyV), Merkel Cell (MCPyV) contribute to specific diseases, but can also be detected on healthy skin. HPyV6 was lymph node a patient Kimura Disease (KD), lymphoid proliferative related ALHE. reported present 4/5 cases ALHE, suggesting possible link between infection development and/or We identified 12 formalin-fixed, paraffin-embedded (FFPE) Endpoint PCR did not identify abundant any cases. Expression HPyV T antigen by immunohistochemistry. In our small case series, there no evidence contributed Further studies may reveal whether HPyVs could indirectly